2013 Harrold and Zavod Med Chem chap 2.indd
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چکیده
This chapter is written with the assumption that the reader has a basic knowledge of organic chemistry and is at least familiar with the terminology used to describe the parts of an organic molecule. The goals of this chapter are to define the term functional group, review the major chemical properties or characteristics inherent to any given functional group, relate these chemical properties or characteristics to the discipline of medicinal chemistry, and to provide some initial examples of how these properties or characteristics are important for drug action. Subsequent chapters provide detailed information with regard to the ionization of acidic and basic functional groups, the roles of water and lipid soluble functional groups, the types of chemical interactions possible between functional groups and their biological targets, the specific routes of metabolism associated with specific functional groups, and how functional groups can be altered to provide a therapeutic benefit.
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تاریخ انتشار 2012